etā hy eveha nṛbhir upagantavyā gatayo yathā-karma-vinirmitā yathopadeśam anuvarṇitāḥ kāmān kāmayamānaiḥ
etāḥ - all these; hi - indeed; eva - certainly; iha - in this universe; nṛbhiḥ - by all living entities; upagantavyāḥ - achievable; gatayaḥ - destinations; yathā-karma - according to one's past activities; vinirmitāḥ - created; yathā-upadeśam - as instructed; anuvarṇitāḥ - described accordingly; kāmān - material enjoyment; kāmayamānaiḥ - by those who are desiring.
In this regard, Śrīla Bhaktivinoda Ṭhākura sings,
anādi karama-phale, paḍi’ bhavārṇava-jale,
taribāre nā dekhi upāya
“My Lord, I do not know when I commenced my material life, but I can certainly experience that I have fallen in the deep ocean of nescience. Now I can also see that there is no other way to get out of it than to take shelter of Your lotus feet.” Similarly, Śrī Caitanya Mahāprabhu offers the following prayer:
ayi nanda-tanuja kiṅkaraṁ
patitaṁ māṁ viṣame bhavāmbudhau
kṛpayā tava pāda-paṅkaja-
sthita-dhūlī-sadṛśaṁ vicintaya
“My dear Lord, son of Nanda Mahārāja, I am Your eternal servant. Somehow or other, I have fallen into this ocean of nescience. Kindly, therefore, save me from this horrible condition of materialistic life.”