dvi-parārdhe - two parārdhas; tu - and; atikrānte - when they have become completed; brahmaṇaḥ - of Lord Brahmā; parame-sthinaḥ - the most highly situated living entity; tadā - then; prakṛtayaḥ - the elements of nature; sapta - seven; kalpante - are subject; pralayāya - to destruction; vai - indeed.

When the two halves of the lifetime of Lord Brahmā, the most elevated created being, are complete, the seven basic elements of creation are annihilated.