guru upekṣā kaile - if one's spiritual master rejects him; aiche - such; phala - result; haya - there is; krame - gradually; īśvara-paryanta - up to the point of the Personality of Godhead; aparādhe ṭhekaya - commits offenses.

If one’s spiritual master rejects him, one becomes so fallen that he, like Rāmacandra Purī, commits offenses even to the Supreme Personality of Godhead.