ātma-sukha-duḥkhe - in personal happiness or distress; gopīra - of the gopīs; nāhika - not; vicāra - consideration; kṛṣṇa-sukha-hetu - for the purpose of Lord Kṛṣṇa's happiness; ceṣṭā - activity; manaḥ - of the mind; vyavahāra - the business.

The gopīs do not care for their own pleasures or pains. All their physical and mental activities are directed toward offering enjoyment to Lord Kṛṣṇa.