śrī-uddhava uvāca
deva-deveśa yogeśa
puṇya-śravaṇa-kīrtana
saḿhṛtyaitat kulaḿ nūnaḿ
lokaḿ santyakṣyate bhavān
vipra-śāpaḿ samartho 'pi
pratyahan na yad īśvaraḥ
sri-uddhavah uvaca -- Sri Uddhava said; deva-deva -- of the greatest among the demigods; isa -- O ultimate God; yoga-isa -- O master of all mystic power; punya -- which are pious; sravana-kirtana -- O You, hearing and chanting the glories of whom; samhritya -- withdrawing; etat -- this; kulam -- dynasty; nunam -- is it not so; lokam -- this world; santyakshyate -- are about to give up once and for all; bhavan -- You; vipra-sapam -- the curse of the brahmanas; samarthah -- capable; api -- although; pratyahan na -- You did not counteract; yat -- because; isvarah -- the Supreme Lord.
As previously mentioned, Krishna's own dynasty can never be destroyed; therefore the word samhritya means that Krishna was taking the Yadavas with Him as He left this material world. However, in the eyes of ordinary, unenlightened persons the withdrawal of the Yadu dynasty appears to be its destruction. Srila Visvanatha Cakravarti Thakura has very nicely explained the statement of Uddhava as follows.
Krishna is addressed as deva-deva, or the supreme God among the gods, because He expertly solved all of the problems of the demigods by His incarnation within the universe. The Lord rid the world of demons and firmly established both His devotees and religious principles. Lord Krishna is addressed here as yogesa because He not only performed work on behalf of the demigods, but also revealed His beautiful, transcendental form, full of transcendental qualities and ecstasies, for the pleasure of His pure devotees. Krishna is called punya-sravana-kirtana because when by His internal mystic potency He exhibited His humanlike activities, the Lord stimulated the writing of innumerable Vedic scriptures about His pastimes. Thus persons who would be born in the future, like ourselves would be able to hear and chant about the Lord's activities and also go back home, back to Godhead.
Having insured the transcendental bliss and liberation of all of His devotees, even those who would be born in the future, Krishna decided the time had come for Him to leave this material universe. Uddhava could understand the Lord's desire and said to Krishna, "You have instructed the Yadavas to counteract the brahmanas' curse by taking bath at Prabhasakshetra, but how could mere bathing in a holy place be of greater value than seeing You, the Personality of Godhead, face to face? Since the Yadavas are always seeing Your transcendental form, and since You are the Supreme Lord, what is the use of their taking bath in a so-called holy place? Therefore You obviously have some other purpose. If You actually wanted to counteract the curse, You could simply say, 'Let this curse not act,' and the curse would immediately be neutralized. Therefore You must be preparing to leave this universe, and that is why You have not counteracted the curse."