nanv artha-kovidā brahman
varṇāśrama-vatām iha
ye mayā guruṇā vācā
taranty añjo bhavārṇavam
nanu -- certainly; artha -- of their true welfare; kovidah -- expert knowers; brahman -- O brahmana; varnasrama-vatam -- among those engaged in the varnasrama system; iha -- in this world; ye -- who; maya -- by Me; guruna -- as the spiritual master; vaca -- through his words; taranti -- cross beyond; anjah -- easily; bhava -- of material life; arnavam -- the ocean.
One's father is a natural object of reverence, as is a religious leader who initiates one into sacred ceremonies and instructs one in general wisdom. But ultimately the bona fide spiritual master, learned in the transcendental science and thus able to take one across the ocean of birth and death to the spiritual world -- such a guru is most deserving of worship and respect, for he is the direct representative of the Supreme Personality of Godhead, as stated here.