prāyaśaḥ - for the most part; puṇḍarīka-akṣa - O lotus-eyed Lord; yuñjantaḥ - who engage; yoginaḥ - yogīs; manaḥ - the mind; viṣīdanti - become frustrated; asamādhānāt - because of inability to attain trance; manaḥ-nigraha - by the attempt to subdue the mind; karśitāḥ - weary.

O lotus-eyed Lord, generally those yogīs who try to steady the mind experience frustration because of their inability to perfect the state of trance. Thus they weary in their attempt to bring the mind under control.