'duḥkha-madhye kona duḥkha haya gurutara?'
'kṛṣṇa-bhakta-viraha vinā duḥkha nāhi dekhi para'

 duḥkha-madhye - among the miserable conditions of life; kona - what; duḥkha - misery; haya - is; gurutara - more painful; kṛṣṇa-bhakta-viraha - separation from the devotee of Lord Kṛṣṇa; vinā - besides; duḥkha - unhappiness; nāhi - there is not; dekhi - I see; para - other.


Text

Śrī Caitanya Mahāprabhu asked, “Of all kinds of distress, what is the most painful?”
Śrī Rāmānanda Rāya replied, “Apart from separation from the devotee of Kṛṣṇa, I know of no unbearable unhappiness.”

Purport

Concerning this, the Lord states in the Vedic literature:

mām anārādhya duḥkhārtaḥ kuṭumbāsakta-mānasaḥ
sat-saṅga-rahito martyo vṛddha-sevā-paricyutaḥ

“A person who does not worship Me, who is unduly attached to family and who does not stick to devotional service must be considered a most unhappy person. Similarly, one who does not associate with Vaiṣṇavas, or who does not render service to his superior, is also a most unhappy person.”

There is also the following statement in the Bṛhad-bhāgavatāmṛta (1.5.54):

sva-jīvanādhikaṁ prārthyaṁ śrī-viṣṇu-jana-saṅgataḥ
vicchedena kṣaṇaṁ cātra na sukhāṁśaṁ labhāmahe

“Out of all kinds of desirable things experienced in the life of a living entity, association with the devotees of the Lord is the greatest. When we are separated from a devotee even for a moment, we cannot enjoy happiness.”