mathurā āsiyā - when he came to Mathurā; rāya - Subuddhi Rāya; prabhu-vārtā pāila - got information of the Lord's itinerary; prabhura - of Lord Caitanya Mahāprabhu; lāga - contact; nā pāñā - not getting; mane - in the mind; baḍa - very great; duḥkha - unhappiness; haila - there was.

After reaching Mathurā, Subuddhi Rāya received information of the Lord’s itinerary. He became very unhappy because he was not able to contact the Lord.