iti-madhye - in the meantime; candraśekhara - the clerk of the name Candraśekhara; miśra-tapana - as well as Tapana Miśra; duḥkhī hañā - becoming very unhappy; prabhu-pāya - at the lotus feet of the Lord; kaila - made; nivedana - an appeal.

While Lord Caitanya Mahāprabhu was instructing Sanātana Gosvāmī, both Candraśekhara and Tapana Miśra became very unhappy. Therefore they submitted an appeal unto the lotus feet of the Lord.